Tretiva is manufactured by Intas Pharmaceuticals. This is an oral retinoid in the capsule form. Tretiva is formulated specifically for severe forms of acne, such as recalcitrant nodular acne, acne conglobata, and acne fulminans. The active ingredient of Tretiva is Isotretinoin, a first-generation retinoid and derivative of vitamin A.
– severe acne vulgaris (cystic, nodulocystic or recalcitrant nodular acne), characterized by red painful bumps, cysts, nodules with a diameter of 5 mm or greater, and painful lesions beneath the skin. It occurs if skin produces too much sebum and pores get clogged, as the acne-causing bacteria P. acnes (Propionibacterium acnes) proliferate inside of a clogged pore.
– acne conglobata, characterized by abscesses and draining sinus tracts in addition to nodulocystic acne symptoms.
– acne fulminans, that develops after an unsuccessful treatment of acne conglobata and is much harder to treat due to its unresponsiveness to the variety of medications.
MOA (mechanism of action):
Isotretinoin is a potent comedolytic, keratolityc, sebostatic, and anti-inflammatory agent. It fights acne by making skin less oily and normalizing follicular keratinization (dead epithelial cells built up in the pores). It reduces the size of sebaceous glands (microscopic organs producing skin oil) so it produces less sebum, while removing the residue of old skin cells from the pores. By these actions Isotretinoin indirectly reduces the amount of P. acnes in the skin.
Tretiva capsules are swallowed whole and taken with food.
The treatment duration is between 16-24 weeks depending on the severity of condition and tolerance.
The daily intake should be divided in two doses.
For adults and children over 12 years:
The recommended starting dose: 0,5-1,0 mg per kg of body weight a day. After a few weeks the dose should be adjusted by the doctor.
For patients with severe kidney problems: 10 mg a day. After a few weeks the dose should be adjusted by the doctor.
For severe skin condition: 2,0 mg per kg of body weight a day as tolerated.
Never exceed the doctor’s recommended dose.
Do not adjust the dose without your doctor’s approval.
Do not take your daily dose of Tretiva® at once.
If you notice any of the more serious side effects, stop taking Tretiva® immediately and seek medical advice.
Women of child-bearing potential must not get pregnant 1 month before starting the Tretiva® treatment course, during it, and 1 month after stopping the course.
Your acne may get worse during the first week of the Tretiva® treatment course. This does not mean you should stop taking Tretiva®. Your skin condition will most likely improve with continuous treatment.
If your acne has not improved after 4-6 weeks of the Tretiva® treatment course, seek medical advice.
Missing a dose
If you miss a dose you should take it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule. Do not apply a double dose.
Do not exceed the doctor’s recommended dose. The symptoms of Tretiva® overdose may include vomiting, facial flushing, cheilosis, abdominal pain, headache, dizziness, and ataxia. If any of these occurs and you are feeling unwell, you should seek emergency medical attention or contact your healthcare provider immediately.
Store at a room temperature from 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Throw away the tube after the expiration date. Keep away from children.